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  •  Clonazepam

Indications

Absence seizures, myoclonic seizures, akinetic seizures, panic disorder, subcortical myoclonus, adjuvant treatment of refractory epilepsy.

Dose

Adult- 0.5 - 5 mg thrice daily, initial dose should not exceed 1.5 mg/day, slow titration is recommended Maintenance dose 4-8 mg daily, Maximum dose 20 mg daily.
Infants and child: Initial dose 0.01-0.03 mg/ kg/day (not to exceed 0.05 mg/kg/day) given in 2-3 divided doses. Maintenance dose 0.1-0.2 mg/kg/day in 3 divided doses.

Panic disorder: Adult- Initial dose 0.25 mg twice daily, usual maintenance dose 1 mg/day, maximum dose 4 mg/day.

Contraindications

Hypersensitivity to benzodiazepines, acute pulmonary insufficiency, acute narrow angle glaucoma.

Precautions

Pregnancy Category: D

Neonates, chronic pulmonary insufficiency, hepatic and renal dysfunction, porphyria, elderly, pregnancy, lactation (Continue lactation; adverse effects possible; monitor infant for drowsiness), avoid sudden withdrawal.

Interactions

Clonazepam decreased level of carbamazepine. Ketoconazole inhibits metabolism of clonazepam.

Adverse Effects

Sedation, dullness, CNS depression, ataxia, bronchial hypersecretion, abnormal eye movement, blood dyscrasias.

 

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