Absence seizures, myoclonic seizures, akinetic seizures, panic disorder, subcortical myoclonus, adjuvant treatment of refractory epilepsy.
Adult- 0.5 - 5 mg thrice daily, initial dose should not exceed 1.5 mg/day, slow titration is recommended Maintenance dose 4-8 mg daily, Maximum dose 20 mg daily.
Panic disorder: Adult- Initial dose 0.25 mg twice daily, usual maintenance dose 1 mg/day, maximum dose 4 mg/day.
Hypersensitivity to benzodiazepines, acute pulmonary insufficiency, acute narrow angle glaucoma.
Pregnancy Category: D
Neonates, chronic pulmonary insufficiency, hepatic and renal dysfunction, porphyria, elderly, pregnancy, lactation (Continue lactation; adverse effects possible; monitor infant for drowsiness), avoid sudden withdrawal.
Clonazepam decreased level of carbamazepine. Ketoconazole inhibits metabolism of clonazepam.
Sedation, dullness, CNS depression, ataxia, bronchial hypersecretion, abnormal eye movement, blood dyscrasias.